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Jacqueline A Lees Selected Research

E2F Transcription Factors

1/2010pRB and E2F4 play distinct cell-intrinsic roles in fetal erythropoiesis.
3/2009Proapoptotic function of the retinoblastoma tumor suppressor protein.
12/2008E2F3 plays an essential role in cardiac development and function.
3/2007Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues.
9/2003E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas.
12/2002E2F4 loss suppresses tumorigenesis in Rb mutant mice.

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Jacqueline A Lees Research Topics

Disease

24Neoplasms (Cancer)
10/2022 - 04/2002
4Carcinogenesis
10/2021 - 07/2008
4Retinoblastoma (Glioblastoma, Retinal)
09/2015 - 03/2009
3Breast Neoplasms (Breast Cancer)
10/2021 - 07/2017
3Neurofibrosarcoma (MPNST)
09/2010 - 07/2008
2Melanoma (Melanoma, Malignant)
01/2020 - 01/2016
1Hyperpigmentation
01/2018
1Ciliopathies
01/2018
1Starvation
01/2018
1Tics (Tic)
12/2017
1Inborn Genetic Diseases (Disease, Hereditary)
07/2017
1Neoplasm Metastasis (Metastasis)
01/2016
1Glioblastoma (Glioblastoma Multiforme)
08/2015
1Sarcoma (Soft Tissue Sarcoma)
06/2012
1Aneuploidy (Aneuploid)
09/2010
1Neurofibromatosis 2 (Neurofibromatosis Type II)
05/2004
1Lymphoma (Lymphomas)
04/2003

Drug/Important Bio-Agent (IBA)

8Retinoblastoma ProteinIBA
05/2013 - 04/2002
6E2F Transcription FactorsIBA
01/2010 - 12/2002
5Proteins (Proteins, Gene)FDA Link
01/2020 - 07/2008
4Ribosomal Proteins (Ribosomal Protein)IBA
09/2010 - 05/2004
3Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
01/2010 - 03/2009
2ClaudinsIBA
10/2021 - 12/2017
2Pharmaceutical PreparationsIBA
01/2016 - 08/2015
1Type C PhospholipasesIBA
10/2022
1taxaneIBA
01/2021
1Paclitaxel (Taxol)FDA LinkGeneric
01/2021
1VimentinIBA
01/2020
1Cyclin-Dependent Kinase 5IBA
01/2020
1Phosphotransferases (Kinase)IBA
01/2020
1NucleosidesIBA
11/2019
1GemcitabineFDA Link
11/2019
1DeoxycytidineIBA
11/2019
1Melanins (Melanin)IBA
01/2018
1Retinaldehyde (Retinal)IBA
01/2018
1TubulinIBA
01/2018
1Small Interfering RNA (siRNA)IBA
10/2017
1CyclinsIBA
07/2017
1ChromatinIBA
09/2015
1Temozolomide (Temodar)FDA LinkGeneric
08/2015
1Messenger RNA (mRNA)IBA
08/2015
1MicroRNAs (MicroRNA)IBA
06/2012
1Cisplatin (Platino)FDA LinkGeneric
02/2007
1Doxorubicin (Adriamycin)FDA LinkGeneric
02/2007
1Cyclin-Dependent Kinase Inhibitor p16IBA
06/2004
1Cyclin-Dependent Kinase Inhibitor p27IBA
04/2003
1Transcription Factors (Transcription Factor)IBA
04/2002

Therapy/Procedure

4Therapeutics
01/2020 - 08/2015